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The high Tg thermoplastic tougheners yield considerable improvements of the composites mechanical properties, especially the interlaminar fracture toughness, as compared to the reference panel.
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It was observed that the SHCC-strengthened panels perform better as compared to the control panel.
These interpretations will be compared to the reference standard diagnoses as determined by the expert pathology panel and to the interpretations of other pathologists in the study.
The optimality probability ℙ(C1) is interpreted as the probability that a given locus is imputed more accurately when using the internal reference panel compared to the external panel.
As the divergence time increases, a small internal reference panel results in increasingly more accurate imputation compared to the large external panel.
We compare two algorithms maximizing phylogenetic diversity (PD) and minimizing average distance to the closest leaf (ADCL and conclude that while both algorithms give better imputation results as compared to randomly selecting haplotypes to be included in the reference panel, imputation accuracy is the highest when minimizing ADCL is used as the method for panel selection.
This study showed that a combination of 1000 Genomes data and a Sardinian reference panel provided the best imputation quality for rare variants, compared to using either reference panel alone.
Although Illumina provides strand information about those SNPs, we still found a few inconsistencies compared with the reference panel.
Using data both from simulations and from the 1000 Genomes Project, we show that the most diverse reference panel can substantially improve the imputation accuracy compared to randomly selected reference panels, especially for the imputation of rare variants.
We impute regions with lengths of 100 kb, 500 kb, 1 Mb, and 2 Mb, using both the most diverse reference panel and 50 random reference panels, each of which is compared to the true underlying genotypes; the mean of the 50 discordance rates is then compared with the discordance rate for the most diverse reference panel.
Further study is warranted to compare the reference panels and related approaches exhaustively.
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