Sentence examples for as bso from inspiring English sources

This can be achieved by inhibitors of GSH synthesis such as BSO, a selective and irreversible inhibitor of γ-glutamylcysteine synthase, the rate limiting enzyme of GSH synthesis (Han and Park, 2009).

As glutathione synthesis is probably only inhibited as long as BSO is present, experiments were repeated with 4 h incubation of GLC4 and GLC4/ADR cells with rhein or doxorubicin, immediately following glutathione depletion.

Therefore, the intracellular GSH concentration is proposed as a potential molecular marker for cisplatin resistance in glioma, and the use of GSH inhibitors, such as BSO, in association with cisplatin and TMZ seems a promising approach for the therapy of this tumor.

Therefore, it is becoming clear that exogenous or endogenous compounds possessing the potential for protein covalent binding display very different effects on the Nrf2/Keap1 and NF-κB pathways, whereas agents such as BSO that deplete GSH– may have similar effects on both redox-sensitive transcription factors.

Furthermore, they indicate that in the liver of the Sprague-Dawley rat the major pathway of CHCl3 biotransformation is its oxidation and that pretreatment of rats with a GSH-depleting agent (such as BSO) is more relevant than PB induction in enhancing the biochemical damages produced by CHCl3.

Thus, the intracellular glutathione concentration is a potential molecular marker for cisplatin resistance in glioma, and the use of glutathione inhibitors, such as BSO, in association with cisplatin and TMZ seems a promising approach for the therapy of such devastating tumors.

Matthews affectionately refers to those bikes with nothing left but the frame as BSOs, or bicycle-shaped objects.

In contrast, conditions that will result in decreased levels of GSH, such as BSO-treatment, will enhance the synthesis of IL-10 leading to a Th2 CD4+ T cell response).

Finally, our observation that ROS sensing can be obtained when GK/Par islets are challenged, with low H2O2 concentrations in the presence of BSO (as are the Wistar islets in the absence of BSO), also supports the notion that the enhanced AOD are detrimental for insulin secretion.

Cells were treated with nothing (control), estradiol, BSO, or BSO plus estradiol for 48 h. Figure 4c shows that BSO plus estradiol treatment reduced Rh123 fluorescence in MCF-7 2A MCF-7 2A approximately 50% cellsred to control, whereas, estradiol or byO, approximately treatments, did not significantly alter Rh123 retention levels in these cells.

More things fell into place as the BSO and the Royal Philharmonic Society in London came on board to co-commission the work.