Exact(4)
All the included studies were reported as being randomised, however for the majority of studies (n = 41) the method of randomisation was unclear (Category 2) and concealment of allocation was rare.
Trials were clearly defined as being randomised and/or controlled in some included reviews.
For sample size, the number of participants reported as being randomised was recorded.
All three studies were described as being randomised and double-blinded.
Similar(4)
Patients (n = 315) with active AS were randomised in a 2 1 ratio to receive adalimumab 40 mg every other week or placebo for 24 weeks followed by open-label adalimumab for up to 5 years.
Inserting a CVS is a routine part of emergency treatment; the CATCH trial arms were very similar and there was little change in a child's care as a result of being randomised to the trial.
Moreover, inserting a CVS is a routine part of emergency treatment and there was little change in a child's overall care as a result of being randomised to the trial.
From a list size of 100,000 (approximating to one location), with twice as many participants being randomised to the intervention group, we estimated the yield of participants randomised to the group sessions was 1.4 per week, allowing us to recruit eight participants to a new group starting every six weeks.
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