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In addition, laboratory testing of hemoglobin or other measures of blood loss such as base excess may not be available in some resource-limited settings; this is especially true during disasters and humanitarian emergencies.
Metabolic acidosis was defined as base excess (BE) lower than -3 mmol/L.
Because the pigs in the study by Clavijo-Alvarez and coworkers [ 12] reached a lower cardiac output than did the sheep in our study, changes in surrogates of hypoperfusion such as base excess bicarbonate and bladder PCO2 were more pronounced.
One consistent feature of severe malaria throughout the world is that mortality is linked to markers of metabolic acidosis, such as base excess (Ref. 3) or hyperlactataemia (Ref. 204).
The most notable finding in this study was the change in patient acid-base status, reflected by both reduced intra-dialytic shifts and increased pre-dialysis steady state levels of pH as well as base excess.
Beyond pH, several approaches have been proposed to assess the hemodynamic failure [ 16, 17], such as base excess, lactate, decreased strong ion difference (SID), increased anion gap, increased venous to arterial difference in partial pressure of carbon dioxide (PCO2) and its ratio to the arterial-venous oxygen content.
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The three independent glucose measurements are also all positively correlated (five of six ρ > 0.62 with p < 10-8, exception: muscle and lab glucose correlation was not significant with pressors on due to lack of sufficient concurrent samples), as is base excess with pH (ρ = 0.66 and 0.89, both p < 10-16).
The central venous oxygen saturation increased from normovolemia, whereas the partial arterial tension of oxygen and the partial arterial tension of carbon dioxide (data not shown) as well as the base excess and lactate were stable during the experiment, with no significant changes between the volemic levels or respiratory modes.
Even though the is pH is the most commonly used measure, we included additional measures such as following: Base excess (BE) – is often used in the clinical setting as a sign for metabolic hypoxia, but is often false positive [ 53].
Objective: To determine performance of makers of tissue perfusion such as lactate, base excess and pCO2 gap (central venous to arterial carbon dioxide gap) at baseline in patients of sepsis and correlate them with predicting mortality in these subsets.
Metabolic acidosis was defined as standard base excess of -5 or less.
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