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Therefore, additional functionally relevant p27kip1 SNPs may exist.
RNA splicing and editing are developmentally regulated, and generate additional, functionally different receptors 13, 14, 15.
The enrichment analysis produced a number of additional functionally-related gene groups associated with variable expression.
However, most members have not been functionally characterized leaving the possibility of additional functions.
The full lists of St-GIs in yeast and worm are provided as Additional files 1 and 2. As molecular function can be inferred from protein structure, we hypothesized that St-GIs will tend to involve functionally similar proteins.
We note that while it is possible to reduce the large functional networks into smaller ones by only keeping edges with a weight above a certain threshold, we find that, for all approaches we tested, by keeping all interactions, we find additional 'unique' functionally enriched clusters as well as an increase in the number of proteins in functionally enriched clusters.
It is worth noting that six of these functionally important genes (bsk, abd-A, Hsp83, Rho1, dlg1, and arm) are implicated by GO analysis to function in reproduction (GO analysis is available as Additional file 3: Table S2).
More, it overlooks the need of buildings to adapt, atmospherically as well as functionally, to the purposes they serve.
All 10,315 nsSNVs found in the Pathan genome were further scrutinized for their possible functional effects using computational prediction methods (SIFT and Polyphen2), resulting in 43 nsSNVs in 43 genes being classified as functionally damaging (Additional file 5: Table S4).
The expression profiles of the genes encoding the components of the costamere, filament system and Z-disk of muscle, as well as their functionally related paralogs (see Additional File 1) were plotted in three dimensions to include (1) the expression level of myoblasts, (2) the expression level of myotubes and (3) muscle specificity (see Additional File 2).
Out of 646 SNPs we detected 19 as functionally relevant polymorphisms (Additional File 10, Table S4).
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