As it can be seen from Figure 7, it is possible, using the inlet temperature as the variable input, to obtain a reliable reconstruction of the trend of a TRT curve.
For many years, the impact of excipients, or more specifically the impact of variability in excipient properties, on the CQAs of pharmaceutical products was treated as an uncontrolled, poorly understood variable input to the manufacturing process.
Different scenarios assume each of the variables as an input variable and investigate the test data and finally select the best scenario.
Any of the above mentioned input variables can be considered as an input variable.
The solution is investigated numerically by means of numerical simulations, using the European and FTP driving cycles as standards for a time-variable input.
The total number of medical personnel, other technical personnel, and the number of non-medical personnel was used as an input variable by Cheng et al. [13] who used variable numbers of doctors, nurses, and the number of administrative and other staff.
The sole input for the system was m-xylene, which was defined as an input variable i.e. one having a constant concentration along the simulations, [ 21].
Sensitivity analysis of its weights showed an important impact of the contact angle as an input variable.
As an input variable takes its realization according to its probability distribution, the two PIMs can quantify the possibility of reducing the variance of the output performance function and the possibility of improving the structural system reliability, respectively.
The addition of time as an input variable to surrogate models provides an extension of the methodology to safety studies where the resolution of time-varying output is important.
