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In the past few years, collagen matrices (CM) have been studied as a valid substitute for free gingival grafts, in particular the porcine CM Mucograft (Geistlich Biomaterials GmbH, Baden-Baden, Germany).
Several studies have concluded that the available measures of Me were not sufficiently accurate as a valid substitute for a permutation procedure (Han et al. 2009; Salyakina et al. 2005; Galwey 2009).
The equation, with the use of routine biochemical variables, needs to be confirmed in free-living populations but can be recommended as a valid substitute for the direct measurement of serum osmolality in existing data sets and could usefully be used to screen for current dehydration in clinical situations.
Similar(56)
In assays where C646-induced fluorescence interferes with measurements, C107 appears to be a valid substitute as it lacks the intrinsic fluorescence properties of C646.
Displacement interactions were as frequent as aggressive interactions, seemed to be most reliable for computing hierarchy parameters and constitute a valid substitute to decided aggressive interactions to build hierarchies.
This was again important for simplification of future protocols as arterial cannulation could be omitted if venous sampling was proven to be a valid substitute.
This study reported that oral fluid was a valid substitute for serum sampling for patients on chronic oral morphine therapy.
However, for healthcare researchers around the world who did not have a readymade CMI at hand, the search for a valid substitute has always been a painstaking process.
With an accuracy of 92%, it can represent a valid substitute for traditional approaches, which are costly, time-consuming, and potentially unreliable.
Two Norwegian studies have shown that CDR staging is a valid substitute for a dementia assessment among nursing-home patients to rate dementia and dementia severity [ 60, 61].
How confident we must be that a surrogate endpoint is a valid substitute for the endpoint of primary interest is debated [ 44, 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com