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The folded backbone conformation imposed by the capping structure could serve as a template for a rational design of drugs targeting class B GPCRs in several diseases.
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In parallel, the recent finding of N-cap motifs which orientate the N-terminal part of members of VIP/secretin family, and are presumably involved in receptor activation, may serve as a template for a new rational drug design.
To develop such compounds, we used QN as a template for rational chemical synthesis and created a series of over 60 novel small molecules.
These evolutionary mechanisms provide a template for the rational design of new proteins from fragments of existing proteins.
Most importantly, knowledge of PPISs and HSs can be used for rational design of therapeutics and biomolecules by serving as a template for the de novo creation of small molecules with enhanced efficacy and selectivity.
As a template for reform, this is a starting point.
We used the cell lysate as a template for PCR.
Brindley Place now stands as a template for urban regeneration.
This indicated that the azoxy motif could prove useful as a template for anthelmintic discovery, possibly creating a class of anthelmintic with novel skeletons, a potential new mode of action, and providing further insight for rational drug design.
Next, linear DNA template was prepared using P22 and P23 to be used as a template for in vitro transcription.
"So then it's been used as a template for every comedian since".
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