The phrase "as a tdp" is not standard in written English and may not be widely understood without context.
It could be used in specific contexts where "tdp" is defined, such as in technical or industry-specific discussions.
Example: "As a TDP, I am responsible for overseeing the project development phases."
Alternatives: "as a team development professional" or "in my role as a TDP."
In the proposed sub-bank Dual Port (DP) memory architecture, SP SRAM has been modified to function as a TDP SRAM, with high throughput and less power consumption.
In 2003, in an effort to provide such a screening process, Redfern et al. evaluated the clinical TdP risk of many drugs, proposed that a measure of [hERG IC50]/[EFTPCmax] be used as a TdP risk indicator, and that a value of 30 or over is a provisional safety margin.
Use of ATGMet85 as a TDP-43 start codon has previously been shown in cell culture studies, however, the physiological relevance of this was unknown [ 17].
The first type of possible regulation occurs at the genetic level and can apply to the THIC gene promoter as it contains a TDP-dependent riboswitch [ 15].
It is therefore possible that cases of AD bearing expansions, like those with FTLD or MND [ 6- 12], should show p62 changes in the hippocampus and cerebellum, as well as a widespread TDP-43 proteinopathy.
Of the 10 previously identified TDP-43 binding miRNAs miR-181a1-3p was omitted in this study as the effect of a TDP-43 knock-down was only marginal compared to other miRNAs [ 14].
Use of ATGMet85 as an alternative TDP-43 start site has been reported previously in cell culture studies showing that TDP-43 species of 35 kDa can be generated independent of caspase-3 cleavage [ 9, 17, 29].
Sotalol has been used as a pharmacological challenge and is documented as inducing TdP in a patient carrying a hERG channel mutation (Lehtonen et al., 2007; Couderc et al., 2009).
The relative ratio of insoluble to soluble TDP-43 was used as a measure of TDP-43 aggregation propensity.
The present study shows that aged PGRN-deficient mice present with NCL-like pathology as well as TDP-43 aggregates in the VPM/VPL, where a particular vulnerability has been reported in NCL model mice.
Another caveat of this analysis is the focus on QT interval measurements as a surrogate for TdP.
