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Sarcoidosis is a systemic entity characterised by the development of non-caseating granulomatous inflammation [22].
IBD has been long ago recognized as a systemic inflammatory entity and as such, it is anticipated to induce changes exceeding the boundaries of bowel mucosa, being reflected in a broader spectrum of tissues, including blood [ 16- 19].
General systems theory [35] provides a conceptual framework within which systemic entities can be organized.
But Van Reisen sees it as a systemic attempt at intimidation.
IgG4-related disease is a systemic syndrome classically considered as a distinct entity belonging to the differential diagnosis of MP.
Hypoxic Pulmonary Vasoconstriction (HPV), although regarded as a physiological process that preserves systemic oxygenation, is also regarded as a pathophysiological entity predisposing to heightened pulmonary artery tones and subsequent pulmonary hypertension [ 1].
According to the World Health Organization (WHO) classification [ 30], primary DLBCL of the CNS was categorized as a subclassification of the DLBCL rather than as a separate entity due to indistinguishable morphology from systemic DLBCL.
International efforts have launched the microbiome era the systemic study of a microbial community as a functional entity (2 5).
The World Health Organization classification of lymphoid and haematopoietic tissue tumours does not recognise PCNSL as a separate entity, as they are indistinguishable morphologically from systemic diffuse large B-cell lymphoma (DLBCL) (Campo et al, 2008).
As a result, some entity — or several entities — have political jurisdiction over the problem.
Top: The chord as a single entity.
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