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It is important to realize that obesity acts not only as a local biomechanical factor, but as a systemic component [ 4] and its influence increases with age: Body composition changes with age, even if body mass index (BMI) does not vary, with an increased proportion of fat mass and decrease in lean mass.
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However, given the possibility that SPA-induced ARDS may have a systemic component (as suggested by mild hypotension in two of the SPA-injured animals), further delineation of the systemic effects of SPA-associated ARDS should occur first.
We conclude that IFN-γ functions as an acute-phase cytokine in both models of liver regeneration and may constitute a systemic component of liver regeneration.
Our results suggest that an adjuvant regimen employing ECF as the systemic component before and after concurrent chemoradiation with continuous infusional 5-FU can be delivered safely and with acceptable toxicity.
Our finding may support that OA has an important systemic component, and not only a mechanical loading component.
Localized primary cancer is usually treated with curative intent with local treatments such as surgery and/or radiotherapy often in combination with a systemic therapy component for the elimination of micrometastatic disease.
But Wheeler, from a similarly Heideggerian position, claims that the way to address the "inter-context" frame problem, as he calls it, is with a dynamical system in which "the causal contribution of each systemic component partially determines, and is partially determined by, the causal contributions of large numbers of other systemic components" (Wheeler 2008, 341).
Nonetheless, additional studies in this direction may help us to understand cancer as a systemic disease and potentially to develop treatment strategies targeting the 'organ component' and 'systemic component' of cancer.
You don't get a sense of this as a systemic problem.
Mediastinal and hilar lymph node enlargement can occur in isolation or as a component of systemic amyloidosis (Figs. 8b and 13) [27, 42].
However, these studies mainly analysed leucocytosis as a component of systemic inflammatory response syndrome (SIRS) and/or as an aspect of vasospasm pathogenesis.
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