Sentence examples for as a substantial problem from inspiring English sources
Multidrug-resistant A. baumannii has emerged as a substantial problem worldwide (2 ).
The risk of becoming HIV infected in their daily work was acknowledged as a substantial problem: It's very dangerous to work in the CHS.
Confounding by indication, which is conceived as a substantial problem in observational studies of treatment efficacy, usually refers to a situation in which patients who are more in need both receive more care have a higher risk of adverse health outcome [ 8].
Racial disparities in the management and outcomes of chronic diseases, such as diabetes, remain a substantial problem for the quality and equity of health care nationally.
Though a relatively small city (approximately 300,000 residents), urban sprawl and roadway vehicle congestion is a substantial problem, as a large number of tunnels and bridges lead to traffic bottlenecks, and some highway segments rank among the twenty most congested outside of Los Angeles and New York City [ 23].
False-positive PCR amplification did not appear to be a substantial problem, as shown by consistently negative results for water and host-cell-only samples and the fact that the genotypes of clinical strains did not resemble common laboratory strains that would be the likely source of any contamination.
However, as allele specific gene expression is due to differential DNA methylation, this may not present a substantial problem here, as Dipterans have lost the main methylation enzymes in their evolutionary history [ 43].
But, he warned, "It does leave us with a substantial problem in the next year -- as we have to make these major infrastructure investments -- about where we're going to get the capital".
This is a substantial problem for spotted-tailed quolls, as they kill relatively large possums and cannot finish their meal before devils arrive.
