"History would say that we're going to have a substantial issue in one of the first three flights.
These concerns point to substantial issues in the methodology of the social sciences.
"It means we have a substantial issue likely to result in reversal," she said.
For that reason, it says, the court should interpret the statute as it did in the Zadvydas case, to avoid what would otherwise be a substantial issue of due process.
Both plots and tests indicated that publication bias in our meta-analysis was not a substantial issue.
This is a substantial issue requiring attention.
Second, data provenance is another substantial issue in predictive toxicology.
"The relevant issue is that this change that he's advocating is going to directly benefit, tangibly and substantially, the investment industry itself; and, inasmuch as Goldman Sachs is a substantial participant in the investment industry, Goldman Sachs.
As Owen Jones points out, even UKIP back "a substantial increase in the minimum wage".
But it has become a contentious issue in the music industry, with some parties concerned that artists could lose substantial royalties as a result.
