The phrase "as a substantial cause" is correct and usable in written English.
It can be used when discussing the significance or importance of a particular factor in contributing to an outcome or effect.
Example: "The researchers concluded that climate change acted as a substantial cause of the recent extreme weather patterns observed globally."
Alternatives: "as a major factor" or "as a significant contributor".
All of these, not only because they have the imprimatur of WHO but also because their content is compelling, enter the consciousness of politicians, bringing awareness to them of headache as a substantial cause of public ill-health [15].
It was first identified in children with respiratory diseases in the Netherlands and is now recognized as a substantial cause of acute respiratory infection in pediatric patients (1 ).
Surveillance for invasive methicillin-resistant Staphylococcus aureus (MRSA), which had long been recognized as a significant nosocomial pathogen, was added to surveillance in 2004 because it had emerged as a substantial cause of invasive infections in the community (3 ).
Human metapneumovirus (HMPV) is now recognized as a substantial cause of acute respiratory infection, particularly in children; it has phenotypic and clinical characteristics that are similar to those of respiratory syncytial virus (RSV) (1, 2 ).
Although, group B streptococcus is a leading cause of meningitis in neonates, this organism has been recognized with increasing frequency as a substantial cause of meningitis in later age groups [ 45].
Of HIH's $3.2 billion hole, FAI's share may turn out to be as much as $600 million–"probably a substantial cause of the collapse," said panel lawyer O'Bryan.
The ITC, after considering the petition, ruled 4-0 Frinay in favor of the two companies, finding that solar cells "are being imported into the United States in such increased quantities as to be a substantial cause of serious injury to the domestic industry". The commission will now weigh what remedy to suggest.
They still cause major health problems in Africa; in areas such as central Tanzania, this disease is a substantial cause of child deaths (4, 6 ).
Nosocomial bacterial infections constitute a substantial cause of morbidity and mortality in developing countries such as Nigeria.
But some in the legal world of pet trusts saw the surrogate's decision as a substantial victory for their cause.
