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Under alternating-current (AC) electric field such films of nanostructured LC exhibit a gradual increase of light transmittance with the increasing voltage, a reversible EO behavior of transmitted light, as well as a specific effect of slightly varying amplitude-frequency EO modulation at the doubled frequency of the driving electric field.
The latter appears less likely as a specific effect, because similar ligands should occur in other proteins.
While this did not preclude detection of IKr reduction as a specific effect of the N996I-HERG mutation, the electrophysiological immaturity of the hESC-CMs might have influenced the impact of IKr reduction on APD, where we observed a significant prolongation of APD50 but not of both APD50 and APD90 as observed in hiPSC-CMs.
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53 On the basis of low transition rates, high responsiveness to simple interventions such as monitoring, a specific effect of cognitive therapy on the severity of psychotic symptoms, and the toxicity associated with antipsychotic drugs, we would suggest that antipsychotics are not delivered as a first line treatment to people meeting the criteria for being in an at risk mental state.
However, impaired executive control alone cannot explain the difficulties with future personal event generation in PTSD, as we found a specific effect in response to positive cues, whereas executive control deficits should affect answers to both cue types.
Polymorphisms in noradrenergic genes, such as alpha-2A-adrenergic receptor gene (ADRA2A) or SLC6A2, may have a specific effect as proposed on MPH response [ 13, 21, 34].
Increased Ets-1 expression was found to be a specific effect as the protein levels of two similar Ets family members, Ets-2 and PEA3 were not altered in this model of Ets-1 over-expression (Figure 2).
This is not even a specific effect: as a similar blocking of colonization occurs with the addition of an antibody to OmpU, the bacterium's major outer membrane porin (Aeckersburg et al., 2001).
Here, we define TF binding as functional if it has a specific effect on the transcript levels of its target gene (Gao et al., 2004).
Recently, RASSF6 expression has been shown to inhibit the basal levels of NF-κB activity in a lung epithelial cell line and this appears to be a specific effect as RASSF2 (the closest family member) exhibited only a modest effect on NF-κB activation [198].
As urban environments seem to have a specific effect on brain function and behaviour it may be interesting to look into what is known about its counterpart - the natural environment, including urban green spaces.
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