The phrase "as a significant obstacle" is correct and usable in written English.
You can use it when discussing challenges or barriers that impede progress or success in a particular context.
Example: "The lack of funding has emerged as a significant obstacle to the project's completion."
Alternatives: "as a major hurdle" or "as a considerable barrier."
China's ambivalence about the openness essential to contain the virus is seen as a significant obstacle.
That plan stalled the bill two years ago and was looming as a significant obstacle again this year.
The reason that the second album came to be viewed by rock critics as a significant obstacle is that most cultural successes depend for their initial impact on what the late Robert Hughes called "the shock of the new".
Policy Points: Historically, in addition to economic and technical hurdles, state and federal health information privacy laws have been cited as a significant obstacle to expanding electronic health information exchange (HIE) in the United States.
Indeed, in an age where computer-accessible databases promise to facilitate research and learning, the permissions requirement can stand as a significant obstacle to realization of that technological hope.
New Mexico Gov. Bill Richardson, chosen by President-elect Barack Obama to be commerce secretary, withdrew from consideration yesterday, citing an ongoing federal "pay-to-play" investigation involving one of his political donors as a significant obstacle to his confirmation.
As HuffPost has reported, a significant obstacle to progressive reform is that Bean and 15 other New Dems on the committee have effective veto power.
While dilute acid pre-treatment reduces the recalcitrance of lignocellulose, the concomitant formation of inhibitory aldehydes such as furfural and 5-HMF represents a significant obstacle to overcome in making lignocellulosic biofuels through CBP a viable alternative.
A significant obstacle often cited as delaying the implementation of these systems has been concern regarding the ability to properly ensure the security and privacy of this sensitive information.
A significant obstacle facing notothenioids as they radiated into pelagic habitats was the ancestral absence of a swim bladder, the gas-filled chamber that most teleosts use to maintain buoyancy.
