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Automakers would see such a weight gain as a significant drawback.
Since fault tolerance is not an important issue in this case, MPIs' lack of fault tolerance mechanism does not come as a significant drawback here.
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The contemporary civic republican interpretation carries with it what could be seen as an significant drawback, namely, it reduces dramatically the distance between classical republicanism and the mainstream liberal tradition.
Xing is quite strong in parts of Europe, where the company set up offices in Hamburg, Barcelona and Istanbul, but the site never gained a foothold anywhere else: Being almost unknown in the USA and Asia is a significant drawback as far as business networking in a highly globalized economy is concerned.
Furthermore, they include a substantial amount of splitters, which is a significant drawback as they degrade the signal strength in the circuits.
This is a significant drawback, as buildings are inherently spatial objects and qualitative spatial relationships accordingly play an important role in the analysis and verification of building models.
For gated and dynamic studies, the sinogram format is however a significant drawback as the sinogram size multiplies with the number of phases or time frames.
However, only considering the cost of implementation has a significant drawback: as mentioned in the beginning, the cost of shutting down a highly critical node will certainly eliminate an attack surface and involves almost no costs at all for implementation.
Nonetheless, markedly enhanced UCP2 expression in non-transformed cells (primarily induced by fatty acids) may become a significant drawback as shown in pancreatic β cells of obesity-associated (type 2) diabetes.
Fast capacity degradation is a significant drawback hindering La Mg Ni-based aLa Mg Ni-basede alloysation as anode electrode materials ofromckel metal hydride batteries.
But this ambitious option has a significant drawback.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com