The phrase "as a selectivity" is not correct and does not convey a clear meaning in written English.
It is unclear in what context it could be used, as "selectivity" typically refers to the quality of being selective, but the phrase lacks clarity.
Example: "The experiment was designed to measure the effectiveness of the drug as a selectivity, but the results were inconclusive."
Alternatives: "as a criterion" or "as a measure of selectivity".
A constriction site with a pore-facing phenylalanine and arginine is proposed to serve as a selectivity filter as well as a gate modulating the conductance state of the channel.
We designed an amplified detection strategy for the sensitive determination of lead ions (Pb2+) based on a target-triggered nuclear acid cleavage of Pb2+-specific DNAzyme as a selectivity interface combined with Pd-Pt alloys modified Fe-MOFs (Fe-MOFs/PdPt NPs) hybrids acting as the signal tag.
The pyrrole moiety with a radical in the 1-position is also found as a selectivity feature towards COX-2 (substructure b in Figure 9).
These considerations raised the possibility that the hydrophobic binding site might serve as a selectivity filter [24].
In this paper, we describe a small-molecule, virtual ligand screening approach that targets the pY-peptide binding pocket of the Stat3 SH2 domain at three sites including a hydrophobic pocket, which served as a selectivity filter.
The use of molecular modeling to delineate the structural basis for competitive inhibition of Stat3 SH2/pY-peptide binding by our compounds identified the hydrophobic binding site as a selectivity filter.
The transfection of functional Orai1 mutants, such as R91W, a selectivity mutant, and L273S, a coiled-coil mutant, into the cells significantly decreased both SOCE and the rate of Tg-induced apoptosis.
A selectivity as high as 99.3% is available on the 3Pt-10Fe3O4/MCNT at a conversion of approximately 60%%.
From the 445 peptides examined manually, a further 11 sites were identified (a sensitivity of 88%) and 14 were assigned as negative, giving a selectivity of 85.1%.
Suramin was not cytotoxic at concentrations as high as 1 mM and had a selectivity index greater than 12 500.
As such, a motif with a selectivity ratio greater than one indicates that the motif is more prevalent in the positive set than in the negative set.
