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Interestingly, primary astrocytes may have even been more suitable as a selection model in vitro in lieu of directly selecting against primary Müller cells, as proteomic profiling studies of primary Müller cells in culture revealed a loss of cellular identity with significant shifts in expression that suggested a dedifferentiation into a fibroblast-like phenotype [38].
Training was initially designed as a selection model, resembling the training of sniffer dogs.
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As a second approach to assess the fit of individual loci to a selective sweep model, we also employed a goodness-of-fit (GOF) test that contrasts the null hypothesis H0 that the data are drawn from a selection model as simulated by the CLRT, to the alternative hypothesis HA that the data are not drawn from such a model (Jensen et al. 2005).
In fact, among these mechanisms are two extreme cases known as a conformational selection model and an induced fit (or induced folding) model, which are also applicable for the description of the peculiarities of protein interaction with small molecules.
To simplify the analysis process, we simplify the analytical model as a binary selection model.
For the same analysis on the p53 gene, KA/KS was low and neutral models were as likely as selection models (Tables 1, 2).
We adopt an approach based on a logistic selection model, as previously used in conventional MAs [ 18, 31].
In Ghana, we find little evidence of selection bias as our selection model gives an HIV prevalence estimate of 1.4%9595% CI 1.2%1.6%.6%), compared to 1.6% among those with a valid HIV test.
As such, this article uses a sample selection model, similar to a model by Heckman [14], modified to account for ordered responses.
In this method, a certain clade (prokaryotes, eukaryotes, extremophiles, and archaea) was selected as foreground set for which a positive selection model was applied while the null model was applied for the other clades of tree (considered as background).
33 As a result, the Heckman selection model is preferred because it gives a better estimated value of WTP/QALY.
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