As an additional second endpoint there was also no difference in the incidence of liver involvement, a site where the first-pass effect would lead to the assumption of a local efficacy of the study compound.
Microsoft notes that it is committed "to the Mac as a first-class endpoint" and that it continues to invest in the platform.
Additionally, the percentage of MPH-LA- versus placebo-treated treatment failures at the end of the 6-month maintenance of effect phase (week 40) was used as a third primary endpoint to assess the maintenance of effect of MPH-LA.
An HSS score of 60 points was chosen as the second endpoint to give importance to patient satisfaction.
The development of ESRD was used as the first endpoint, and increased proteinuria was used as the second endpoint only for those patients at the early stage.
The aim of this study was to investigate effects of PPI versus H2RA on the occurrence of VAP and, as second endpoint, the occurrence of gastrointestinal bleeding (GIB).
Apart from the determination of insulin reserve as a biological parameter a second primary endpoint was defined as 'therapeutic failure' according to the criteria of the European Association for the Study of Diabetes.
Survival rate considering the second endpoint defined as "prosthesis revised for mechanical failure or infection" was also significantly lower (p = 0.002) in the PTA group (94%, CI: 89 99) than in the PA group (100%, CI: 99 100).
The second endpoint was defined as removal of the prosthesis for any reason or a clinical score below 50.
