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We have defined a treatment effect of factor 2 as a relevant effect, i.e., a hazard ratio (HR) of 0.5.
Thus, depending on the pretreatment seizure frequency a reduction of seizure density to a respective seizure interval e. g. one seizure every 3 months can be considered as a relevant effect.
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On the one hand, an increase of 90 min per week is considered realistic from a practical point of view, on the other hand it is considered a relevant effect as the achieved 150 min per week (assumption: baseline PA = 60 min per week + increase by Movement Coaching = 90 min per week) would go in line with the WHO recommendations on PA [ 15].
There is also an agreement about the complexity of valence-band effects in QDs as a relevant issue when dealing with optical response from transitions between these completely localized states [7, 17, 18].
As a clinically relevant effect we considered a difference of 15% or more in the probability a patient is still living at home after two years.
As clinical effects were negligible in our sample, potential sources of bias such as a relevant placebo effect are unlikely.
We have defined a clinically relevant effect as a pain reduction of 1.3 point on an 11-point NRS [ 27, 29].
We defined a clinically relevant effect as a maximum pain reduction of at least 1.3 points.
We had defined a clinically relevant effect as a pain reduction of at least 1.3 point on an 11-point numeric rating scale, as this is considered the minimally important difference using this scale [ 26- 28].
Alternative splicing (AS) can have a biologically relevant effect on protein structure, as it allows the shuffling of protein domains rather than disrupting them [ 1].
Yet, the first two RCTs conducted by Jolliet et al. [20] and Maggiore et al. [21] exhibited a reduction in the intubation rate with He/O2 which went well beyond what could be considered as a minimal clinically relevant effect.
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