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Long intergenic tandem repeats are well known targets for structural variation, and in this study we investigate whether exonic STRs share this property, and hence may serve as a probable target for exonic disease causing mutations.
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Collectively, our results suggest that EVI1 is a probable target gene that acts as a driving force for the amplification at 3q26 in HCC and that the oncoprotein EVI1 antagonizes TGF-β-mediated growth inhibition of HCC cells.
Although this was long before Wałęsa emerged as a hero of the Solidarity, questions remain whether it had an effect on his later decisions; for example, making him a probable target of blackmail.
Marshall felt that several factors conspired to make Toronto a probable target.
These combined results suggest that EVI1 is a probable target for the 3q26 amplification in HCC.
The finding of Bmi1 as a highly probable target of miR-300 suggests that it could directly regulate Bmi1.
The Vatican has moved to play down Italian media reports that it had been named as a probable next target for a Paris-style attack.
MDM2 has been identified as a probable therapeutic target for CRC [ 62, 80].
Experimental methods on protein binding to DNA usually locate some DNA segment, or word in DNA text, as a probable binding target.
This is to be expected since one would need more measurements to detect a less probable target as our decision rule weights each target by its a priori probability.
Admiral Chester Nimitz, the new commander of Allied forces in the Pacific, and his staff discussed the deciphered messages and agreed that the Japanese were likely initiating a major operation in the Southwest Pacific in early May with Port Moresby as the probable target.
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