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A number of studies have investigated the utility of the neutral comet assay (NCA) as a predictive method for radiosensitivity with varying results.
We have also used the ToxCast data set to further evaluate whether docking coupled with a hybrid scoring scheme was useful as a predictive method for PXR, especially when screening large data sets of molecules.
The sensitivity and positive predictive value is low (3.6%and4.6.6%), meaning that reports of patients and healthcare professionals are not useful as a predictive method to detect the same adverse events as a patient record study.
The application of CBR to the field of biomedicine is a relatively new field which has been applied to a great variety of medical problems: in health centres as a control method, for hyperthyroidism, for haemodialysis for patients and/or diabetics, for the diagnosis of patient stress levels, and as a predictive method for the evolution of cancers and leukaemia [ 12– 16].
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A predictive method, such as that described, would need to be competitive against these.
One of the greatest challenges faced in the development of a predictive method, such as this, is the need for systematic and impartial performance evaluation.
The Multiple Organic Dysfunction Index was developed in a sample of surgical patients, and since then has been shown as a good predictive method in patients with septic shock.
Microcalorimetry is frequently used as a high throughput predictive method in order to screen different formulations for their storage stability.
As in the predictive method the bioactivity is predicted by calculating the average difference between the predicted value for a compound with and without a given substructure, the (potentially non-linear) relationships between the substructures present in a molecule can be established, and the dependence of bioactivity on additional substructures or scaffolds present in the molecule accounted.
Costs and benefits for each set of measures are computed (see 2.4), by using the calibrated HSM as reference predictive method.
We therefore chose nucleosome exclusion sequences as our predictive method, rather than nucleosome positioning sequences.
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