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Interestingly, we also observed an insignificantly smaller average lateral ventricle volume in HD rats, which is opposite to findings in HD patients (Bohanna et al. 2008), but in agreement with the observations by Blockx et al. (2011), who interpreted this as a possible "pathological enlargement" phenomenon (Paulsen et al. 2006).
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Despite AD and PD being clinically distinct entities, there is a possible pathological overlap.
A possible pathological change in the cell membrane permeability is assumed too.
In the present chapter, we describe the routes of exposure into the body via the lung and factors affecting this, as well as possible pathological reactions to nanomaterials ranging from inflammation and fibrosis to carcinogenicity.
Since APP-BP1 was first identified as a protein that interacts with APP [4], numerous studies have investigated its functions as well as its possible pathological roles in AD [22].
Moreover, with the predicted doubling of the prevalence of type 2 diabetes from 1995 to 2025 [9], clinicians need to be aware of its role as possible pathological basis for a complicated or un-resolving UTI.
On a cellular level, it appears that the PRRT2 protein is predominantly localized to the synapse and that it may participate in neurotransmitter release, suggesting disrupted neurotransmission as the possible pathological mechanism in PKD [ 13].
As possible pathological mechanism we found hypoadiponectinemia in ZDF rats and a downregulation of APPL1 in their mesenteric arteries at mRNA level.
Therefore, vagal overactivity appears as a possible common cause of various pathological processes.
MRI has often a low specificity for differentiating between possible pathological changes which could help in discriminating between the different pathological stages or grades.
Another possible pathological process is a failure of the tight control of betaine efflux from cells.
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