This study found no evidence for an association between either of the two previously identified AS-susceptibility IL-23R SNPs (rs1004819 and rs10889677) and onset of AS, indicating a possible difference in pathogenesis of AS between Chinese and European patients.
Virus replication combined with damage to tissues with the induction of toxic inflammatory cytokines has been proposed as one possible pathogenesis [ 8– 10].
Adverse effects, such as possible pathogenesis, infections or ineffective healing, may significantly delay the process of wound closure.
In addition, our results are consistent with studies in cultured human trabecular meshwork cells, which have proposed a cellular stress response as a possible mechanism in the pathogenesis of glaucoma [12], [13], [15], [41].
Moreover, we provide evidence of cancer- and chemotherapy-related parasympathetic dysfunction – as a possible contributor to the pathogenesis of CV disease in cancer survivors.
Environ Health Perspect 122 1075 1080; http://dx.doi.org/10.1289/ehp.1307413 The identification of respirable silica dust (Parks et al. 1999) and smoking (Sugiyama et al. 2010) as causes of rheumatoid arthritis (RA) suggests inhaled pollution as a possible factor in RA pathogenesis.
M. genitalium has also been studied as a possible contributor to the pathogenesis of trachoma in a trachoma-endemic area of Tanzania, but no evidence was found regarding its contribution (9 ).
Therefore, as a possible explanation for the pathogenesis of nodal metastases in DCIS, we propose that true metastases arise from the occult invasion of the primary tumour and iatrogenic dissemination of benign epithelial or tumour cells during preoperative breast biopsy (Osako et al, 2012).
We are currently exploring this possible pathogenesis as an explanation for the lethality observed in Sulf1−/− Sulf2−/− neonates.
Apoptosis is suggested as a possible contributing factor in the pathogenesis of smoking-induced toxicity.
