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The algorithm is currently optimised for endpoints such as a mutagenicity where the activity is heavily based on the presence of reactive groups and inactivity can be defined as the absence of mutagenic structural features.
V79 Chinese hamster lung cells were used as a mutagenicity test system [ 15].
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44 The MN test is a mutagenicity test widely used as a marker of early biological effects due to its ability to detect both clastogens and aneuploidy-inducing chemicals.
We also noticed that methanolic, aqueous and TOF-enriched extracts were more efficient in reducing B(a)P mutagenicity than 2-AA mutagenicity.
In strain TA97a, the dose response for B. coccolobifolia went up to a mutagenicity ratio of 1.9, giving evidence of mutagenicity.
The solvent in each fraction was removed by evaporation under reduced pressure at 50-55 degrees C, and the residue was dissolved in dimethylsufoxide just before being tested for antimutagenicity as well as mutagenicity using the Salmonella/mammalian microsome mutagenicity test.
The aims of the present study were to determine the antibacterial and antifungal activity as well as mutagenicity of Sechium edule fluid extract and to obtain a pharmaceutical formulation with them.
ER-independent activities of estrogens have recently been elucidated that include cell-signal transduction as well as mutagenicity [ 4, 7- 9].
Current evidence suggests that different DNA adducts may induce very different effects on cell proliferation, cell death via necrosis or apoptosis, as well as mutagenicity, possibly attributable to activation of cellular responses such as p53 activation.
NBA: Initiator of the review, vital fluorescence biofilm research regarding clinical controlled studies; LN: Main author, microbiology and 'dead and alive´ discussion; TMA: CLSM research, Syto 9 and related compounds; AS: Mutagenicity of vital stains, refining and general support in editing.
Additionally, the use of DPX as a surrogate of mutagenicity was proposed to underestimate FA induced cancer.
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