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Pohl, P. C. et al. ABC transporters as a multidrug detoxification mechanism in Rhipicephalus (Boophilus) microplus.
It can be concluded that core shell nanoparticles show potential as a multidrug delivery platform for tumor targeting.
Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in vitro revealed Cel-Pgp-1 as a multidrug transporter.
Clonal group A is known as a multidrug resistant uropathogenic group known to cause UTIs in adults [25].
In Pseudomonas aeruginosa, a 50 kDa outer membrane protein, OprM was shown to be iron regulated with the probable involvement in pyoverdin export, though it was primarily established as a multidrug efflux pump [23].
MVP functions as a multidrug resistance factor [ 51– 51].
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P. aeruginosa isolate is also resistant to ticarcillin, ticarcillin clavulanate and aztreonam due to overexpression of MexAB-OprM efflux pump (Table 4) but did not qualify as a multidrug-resistant (MDR) bacteria according to international criteria [21].
Also, renal cancer patients respond poorly to conventional chemotherapy because RCC is regarded as a multidrug-resistant cancer (Walsh et al, 2009).
The first available E. coli strain from this patient, ECRB1, was isolated from a urine sample in 2007 and was reported as a multidrug-resistant strain harboring blaCTX-M-65 and rmtB (4 ).
A new report has documented that tigecycline as part of a multidrug regimen resulted in improvement in >60% of 52 patients with M. abscessus and M. chelonae infections, including those with underlying cystic fibrosis despite having failed prior antibiotic therapy.
The limited efficacy of chemotherapy may be dependent on the expression of defence factors which confer increased survival potential for tumor cells and, as a consequence, a multidrug resistant phenotype [ 5].
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