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THZ targets different pathways and can thus be used as a multi-target inhibitor itself as well as provide strategies for multi-target drug development for combination chemotherapy.
The promising compound 17f was identified as a multi-target receptor tyrosine kinase inhibitor, which also displayed favourable pharmacokinetic properties in rats, had an acceptable safety profile in preclinical studies, and significant anti-tumour activity in the Caki-1 tumour xenograft model.
Encouraging preclinical and clinical findings suggest that HupA is a promising candidate for the treatment of neurodegenerative diseases such as AD and VD, and is very likely to exert its therapeutic effects via a multi-target mechanism.
(C ) Continuous tracks are obtained by post-processing the feature detections with a Multi-Target Tracking algorithm.
Sunitinib, a multi-target receptor tyrosine kinase inhibitor, was used as a model drug.
In summary, we herein show for the first time that S9 functions as a multi-inhibitor simultaneously targeting both PI3K-Akt-mTOR axis and microtubule cytoskeleton.
The results showed that compound TM-9 could be regarded as a balanced multi-targets active molecule.
Translating this approach into treatment terms we can describe it as a multi-agent multi-target strategy.
Finally, an extension to multi-target scenarios will also be considered.
A full understanding of these interactions is of paramount importance both when assigning the most beneficial treatment to patients and when designing new therapeutic strategies, such as combined modality treatments and multi-target or multiple-hit strategies.
It has been demonstrated that a balanced modulation of multiple targets in parallel can be beneficial for treating diseases with complex etiologies, such as using multi-kinase inhibitors for treating cancer and multi-target monoaminergic ligands for treating CNS diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com