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We use the optimal sub-pattern assignment (OSPA) as a multi-target miss-distance metric [37].
We have previously shown that hyperforin is able to inhibit angiogenesis in an in vivo model and behaves as a multi-target antiangiogenic drug by inhibiting several key steps of the angiogenic process.
As a multi-target compound, celastrol might activate complicated signal cascades in cells.
Celastrol, as a multi-target compound, might have different direct targets and could activate complicated signal cascades.
Our recent review [ 61] highlights convincing evidence from animal and human studies for the potential of prebiotics as a multi-target strategy to treat NAFLD.
These intriguing questions must be addressed in future studies before NC can be further developed as a multi-target drug for cancer therapy.
The difficulty in clarifying the mechanism of celastrol resulted from the capacity of celastrol to act as a multi-target compound.
Therefore, targeting inflammatory pathways may be of benefit as part of a multi-target approach to PDAC therapy.
Additionally, the results demonstrated the promising activity of these compounds with a multi-target mechanism as good candidates for further development into potential anticancer agents.
Validation of the classifier predictions on a multi-target dataset such as this one can be done either based on all predictions in a single confusion matrix or by calculating a confusion matrix per target and subsequently using the mean value.
SAHA, one of the emerging HDAC inhibitor widely used for cancer treatment, has unignorable side effects, as it is a multi-target HDAC inhibitor.
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