The phrase "as a major question" is correct and usable in written English.
It can be used when introducing or emphasizing an important issue or topic that requires attention or discussion.
Example: "In the context of climate change, the sustainability of our resources is often raised as a major question."
Alternatives: "as a significant issue" or "as a key concern".
Banks came into the season as a major question mark after playing sparingly in 2001.
Either way, a player who entered this season as a major question mark appears poised to begin the next one as a staff linchpin.
In particular, the oil and gas explorations are seen now as a major Question Mark, and as a potential sunrise sector in the Arctic region.
These observations raise the neglected issue of niche space in Caenorhabditis biology as a major question to be answered to understand the abundance and distribution of species.
On Saturday in India, Dr. ElBaradei was quoted as saying that "a major question" about the authenticity of the evidence kept his agency from "making any judgment at all" on whether Iran had ever sought to design a nuclear warhead.
As a result, a major question has been raised regarding the function of betatrophin in T2D and its ability to induce β-cell proliferation as well as its physiological role in humans [ 19, 20, 22, 31].
"He's feeling as good as you can feel with such a major question mark hanging over his head," Karen P. Hughes, one of his most senior campaign advisers, said late Wednesday afternoon.
Jimmy Gralton represented that alternative voice and finding a space for dissidents – and also seeing them as important alternative arguments – is a major question of our time".
"Not only is this becoming a joke, it's becoming a major question as to what we should and shouldn't believe from media in general and sports media in particular," Jim wrote.
Whether Democrats will stand and fight against the changes -- potentially at the risk of derailing funds to deal with the crisis -- or accept weakened protections will be a major question as talks move forward.
This is a major question as it raises the clinical usefulness of the MetS.
