The phrase "as a major inducer" is correct and usable in written English.
It can be used in contexts discussing causation or influence, particularly in scientific or technical writing.
Example: "The chemical compound acts as a major inducer of the reaction, significantly increasing the rate at which it occurs."
Alternatives: "as a significant catalyst" or "as a primary driver".
TGF-β has been delineated as a major inducer of EndMT (van Meeteren and ten Dijke, 2012).
TGF-β has emerged as a major inducer of EMT through activation of downstream signaling pathways, including non-Smad signaling pathways [ Figure 1A (33, 33)].
Also, we identified the heat shock factor-1 (HSF1)/mitogen-activated protein kinase (MAPK /c-Jun N-terMAPK /c-June (JNK) axis as a major inducer of DNA-Pkinase HCC cells.
34 In tumor metastasis, TGFβ stimulates angiogenesis by inducing a pro-angiogenic environment and also promotes epithelial mesenchymal transition (EMT) as a major inducer of both Smad-dependent and Smad-independent signaling pathways.
IL-18 was initially identified as a major inducer of IFN-γ [ 9] and were shown to be instrumental in Th1 cell induction and activation in the presence of IL-12 [ 10].
The similarity of the results from identical experiments conducted in freshly dispersed cells from diabetic and control rats, and cultured rat aortic cells grown in normal and high glucose are striking and underlie the importance of chronic exposure to glucose as a major inducer of changes in intracellular Ca2+ regulation.
VEGF, a dimeric and heparin-binding glycoprotein that functions as a potent mitogen of vascular endothelial cells, is a major inducer of angiogenesis that can promote the growth and metastasis of tumors [ 25].
Since our study revealed SOCS2 expression as a predictor for prognosis, and growth hormone is a major inducer of SOCS2, we became interested in the expression of the growth hormone regulated gene IGF-I.
IL12B gene expression is a major inducer of IFNγ and IL12-p40 is required for IFNγ-induced protection from Mtb.
We suggest that PGE(2) is a major inducer for Th17 cells in HNSCC microenvironment.
It is also a major inducer of interleukin-12 production in human monocytes [ 38].
