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Given its effectiveness and tolerability, rituximab is currently being investigated as a maintenance agent with encouraging results.
Azathioprine has equivalent efficacy as a maintenance agent to cyclophosphamide with fewer episodes of leukopenia.
Extended courses of gusperimus as a maintenance agent have been shown to be effective and relatively safe [ 76, 77].
Subsequent studies have explored the combination of ixazomib with lenalidomide in newly diagnosed myeloma, where the combination had high efficacy as well as adequate tolerability to allow for long-term therapy as a maintenance agent.
The antifolate pemetrexed is efficacious in combination with cisplatin for first-line treatment of advanced NSCLC and has shown efficacy as a maintenance agent in studies in which it was not included in the induction regimen.
It should also be noted that the efficacy of A. paniculata extract (HMPL-004) for induction therapy in patients with ulcerative colitis who are failing various combinations of corticosteroids, azathioprine, and anti-tumor necrosis factor therapy with infliximab is unknown, as its efficacy as a maintenance agent.
Similar(53)
The system administrator plays the role of a service provider and of a maintenance agent.
The position of leflunomide as a remission maintenance agent remains uncertain.
This data clearly places methotrexate as a better maintenance agent that MMF since it gave similar relapse rates to AZA.
The findings from these clinical pharmacology studies are synthesized and presented in a framework designed to (1) inform clinicians about the advantages and disadvantages of buprenorphine as an opioid maintenance agent, and (2) provide information about dosing procedures that may optimize the use of buprenorphine in the clinic.
The anti-EGFR monoclonal antibody was investigated as a maintenance single-agent in the NORDIC VII trial, but results were not encouraging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com