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Together, we show B-ALL is a highly glycolytic cancer dependent on Glut1 as a limiting component of glucose and anabolic metabolism.
Despite the incomplete inhibition of glucose uptake, Glut1 deletion led to striking shifts in metabolic pathways that demonstrate glucose transport as a limiting component of B-ALL cell metabolism.
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Taken together, the results of the present study identify Munc18b as an essential gene that is a limiting component of the exocytic machinery of epithelial cells and MCs.
Nitrogen is an essential and limiting component of biogenic polymers, such as nucleic acids and proteins, animals must obtain it from exogenous sources [ 56].
This implies that in each fermentation process to be developed using plant waste streams as substrates, limiting components should be supplemented.
In 2006 a genome wide screen using RNA interference led to the identification of the stromal interaction molecule STIM1 and Orai1 as the limiting components of the CRAC pathway in human T-cells [35 37].
The chip at the heart of D-Wave's latest machine has 512 qubits, but they are wired into a different, more limited, component known as a quantum annealer.
They have been shown to facilitate the intercellular transfer of organelles as well as, on a limited scale, of membrane components and cytoplasmic molecules.
Fatigue is a limiting factor in structural component life.
Substrate space is frequently a limiting resource and, as an immobile component of the hard substratum epifauna, brachiopods have been competing for living space with other epifaunal organisms since the Cambrian.
It is this second component, the necessity for a limiting principle, that underlies this case.
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CEO of Professional Science Editing for Scientists @ prosciediting.com