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The phrase "as a large fraction" is correct and usable in written English.
It can be used when discussing proportions or significant portions of a whole in various contexts, such as statistics or research findings.
Example: "As a large fraction of the population supports the new policy, it is likely to be implemented soon."
Alternatives: "as a significant portion" or "as a considerable percentage".
Exact(20)
As a large fraction of the primary production in most deserts is converted into termite biomass, it would seem logical to develop ways by which termites can be converted into food for humans.
Web Search is increasingly entity centric; as a large fraction of common queries target specific entities, search results get progressively augmented with semi-structured and multimedia information about those entities.
For a given block code with minimum Hamming distance d, it is well known that any erasure pattern containing up to d−1 erasures ([14], p. 81) can be corrected, as well as a large fraction of patterns containing d or more erasures, as long as the number of erasures in a codeword does not exceed the number of parity-check digits and these erasures do not cover a codeword [16].
Data processing by HKL2000 [42], MOSFLM [43] was problematic as a large fraction of data were rejected in all possible space groups (the most likely being P2/P21).
As a large fraction of mRNAs and miRNAs were either not expressed or non-detectable, we filtered out probes with median detection p value≥0.01 (the p values were automatically reported in BeadStudio).
In normal resting cells translation initiation may be very low as a large fraction of eIF4E may be complexed with the inhibitory 4E-BPs in the absence of Akt/mTOR pathway stimulation [28].
Similar(40)
Speaking of species extinctions, the IPCC discussed that serious threat as well, A large fraction of species face increased extinction risk due to climate change during and beyond the 21st century, especially as climate change interacts with other stressors (high confidence).
The method described here is able to correctly classify as plausible a large fraction of the experimentally characterized isoforms, and to highlight dubious cases.
After acid-catalyzed steam pretreatment of lignocellulosic materials, the hemicellulosic sugars are mainly present as monomers, whereas a large fraction of the glucose content is present as glucan in the fibers.
After pretreatment, hemicellulosic sugars, i.e. the pentoses (and also hexoses), are present as monomers while a large fraction of the glucose content is present as glucan fibres in the WIS.
With its wide field of view and high duty factor, HAWC will be an excellent instrument for the studies of diffuse gamma ray emission, the high energy spectra of Galactic gamma ray sources, and transient emission from extragalactic objects such as GRBs and AGN, as well as surveying a large fraction of the VHE sky.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com