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Conversely, Ala11 completely lost the ability to interact with TP5 due to the lack of negative residue in its side chain (Fig. 7B, D), which showed that Glu11 acted as a key effect on the binding between TP5 and HLA-DR.
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As I noted yesterday, a key effect of Woodhouse's attack on Steele is the chilling of Republican dissent on the Afghanistan war - Republican dissent that war critics need in order to end it; and the letter attempts to counteract that effect and to pressure the DNC to not engage in this sort of attack on war critics in the future.
Upregulation of DR4 or DR5, which can occur in a p53-dependent or -independent manner in response to chemotherapeutics (Wu et al, 1997; Sheikh et al, 1998), is often described as a key event in the synergistic effect between chemotherapeutics and rhTRAIL (Wu et al, 2004).
The NRC considered IUI to be a nonadverse precursor effect but relied on this end point as the key effect in their RfD derivation, treating the lowest dose from Greer et al. (2002) as a no-effect level.
Pollak has demonstrated what he and others see as the key effect, which may trigger the other benefits of the drug: It inhibits oxygen consumption in mitochondria, in effect turning down the cell's metabolic thermostat.
Randomized clinical trials (RCTs) of interventions for the hepatitis C virus have historically used sustained virological response (SVR) at 24 weeks after treatment (SVR24) as the key effect measure.
And yet, as a key cause and effect of globalization, the Internet does play an important role in enabling the conditions that produce today's 27 million slaves around the world.
The isoflavone daidzein prevents bone loss by reversing the detrimental immune changes as a result of estrogen deficiency as a key mechanism for antiosteoclastogenic effect [ 12].
Sub-optimal physical growth has been suggested as a key pathway between the effect of environmental risk and developmental outcome.
Our results corroborate this previous proposal in the context of S. pneumoniae biofilms, clearly identifying the phage activated lytic machinery as a key player in this effect.
These results confirm and extend the evidence implicating adiponectin as a physiological modulator of atherogenesis and point to variability in the ADIPOQ gene as a key regulator of this effect.
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