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For example, BAG3 was identified as a interacting partner of MMP-2, knockdown of BAG3 reduced MMP-2 expression, and invasiveness in MMP-2-positive ES2 ovarian cancer cells.
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The lab has lots of data on how individual pathways work, but no one was looking at the pathways as an interacting system.
However, HexDock and PatchDock (Fig. 1b) identified that Thr265 (1.46 and 1.91 Å) is the residue involved in hydrogen bond, where as AutoDock identified Glu 317 (1.79 Å) as an interacting residue (Fig. 1).
In particular, heparin acts as an interacting template that rapidly forces β-sheet aggregation of C-36 to distinct amyloid species within minutes and leads to a more homogeneous fibril population according to solid-state NMR analysis.
PI thus evolves as an interacting phenotype and indirect genetic effects may strongly affect the co-evolutionary dynamics of offspring and parental behaviors.
NTKL has also been identified as an interacting molecule of the adaptor protein 2 (appendagendage that are involved in clathrin-coated endocytic vesicle formation [24].
Thus, as expected for a proper selection by GeminiDistances, the amino acid shown to be important for the oligomerization of the cpn10, is recognized as an interacting one "X".
As can be seen on the interaction network of 1HX5, on the appropriate region (Fig. 3C and Fig. 7A), Ile 5 is identified as an interacting residue "X" by GeminiDistances.
ASPP2 was previously identified as an interacting partner for several proteins, for example, Bcl-2 and p53.
A neurally differentiated embryonal carcinoma-derived protein (Necdin) was isolated as an interacting partner for Gαo from a mouse brain cDNA library using yeast two-hybrid screening.
We have found that rhodopsin serves as an interacting partner and a vehicle for ciliary delivery of a key phototransduction protein, GC-1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com