These factors may include properties of the agent strain, polymorphisms in the host PrP sequence other than at codons 136, 154 and 171, the rest of the host genome as well as further parameters yet to be defined (7, 22).
The silicon nanocrystals have been one of the most important developments in the field, as they offer strong carrier confinement and modification of the energy levels through quantization, as well as the ability to use their surface as a further design parameter, from which we provide a emission model with the four-level system.
This enabled the determination of the crack opening displacement for crack initiation (COD i) as a further local fracture parameter.
Pulmonary artery pressure as a further highly sensitive parameter for functional pulmonary disorders increased over the observation period in all animals (from 22.0 ± 2.2 mmHg to 28.7 ± 3.6 mmHg in controls).
As a further enhancement, the parameters could be dynamically optimized by the network itself according to the self-optimizing network principle.
As a further validity of the parameter values, we tested the wildtype model in other conditions, namely TRAF2 KO, TRAF5 KO, TRAF2/5 double KO, TRAF6 KO, RIP1 KO and TRADD KO. (Note that in silico KOs were generated from the wildtype model by setting the activation parameter value of the KO molecule to null).
During grazing, 30% (parameter λ = 0.3) was released as small, non-sinking material, a further 5% (parameter r = 0.05) being excreted as DOC (providing a growth substrate for free-living bacteria).
In this context it is also of interest that unweighted LTR yielded very good predictions even without the need to specify any further parameter (as necessary for weighted LTR and TRANSWESD).
pneumoniae coinfection with the cytokine data from the single S. pneumoniae infection group, in silico results predicted bacterial clearance as in the single bacterial infection without further parameter fitting (Fig. S5).
We analysed a further eight parameters as indirect markers of good clinical practice.
