Sentence examples for as a further optimisation from inspiring English sources
An ammonia extraction step was introduced in the DCCI analytical procedure as a further optimisation of a previously published procedure [29] as it was observed that certain pigments can strongly interfere in the hydrolysis step, leading to chromatographic profiles different from those obtained from the reference materials.
Since no set of conditions had proven superior for this transformation, Farina's catalyst system 63 ([Pd2(dbAsPh3 AsPh3) was chosen as a basis for further optimisation, with the amount of bis-stannane 92 maintained at two equivalents throughout (Table 3).
As the summation of individual Poisson processes is still a Poisson process, further optimisation has been applied in which a group of ORNs is emulated by a single "compound" Poisson model neuron.
This approach has allowed us to identify several novel APE1 inhibitors that potentiate the cytotoxicity of alkylating agents and that have potential as lead compounds for further optimisation and development.
Hit series 1 a– c were successfully validated and shared an overlapping pharmacophore for TbTryS activity, demonstrating clear SAR and a visible potential for further optimisation.
Therefore, we have designed and synthesised a novel chemical compound with great potential to further optimisation as inhibitor of drug efflux pumps.
The thiazolidinone series, in particular compound 13, presents a good starting point for further optimisation.
"There will be some challenges," admits Simpson, in something of an understatement, "But with some further optimisation I am confident that we will be successful.
Without further optimisation, the present synthesis generates a product with a modest specific activity of 10 GBq/mg (1 GBq/μmol) when starting with 12 18 GBq F. A likely scenario for production for human use is as follows.
