Sentence examples for as a functional polymorphism from inspiring English sources

This study also identified the -3081(A/T) polymorphism as a functional polymorphism that decreases promoter function.

Our results strongly suggest the presence and functioning of MGAM which disproved deficiency predictions based on SNP array analysis findings, classifying the deletion as a functional polymorphism.

Bacterial flagellin has also been implicated in IBDs, as a functional polymorphism in TLR5 was shown to negatively correlate with Crohn's disease [15] and commensal-derived flagellin has been identified as a dominant antigen in this disease [16].

Nevertheless, in vitro functional studies are needed to ascertain them and, if possible, they should be made before considering a variation as a pathological mutation or as a functional polymorphism.

MMP1-1607 (1G/2G) is a functional polymorphism, as it alters MMP-1 expression.

The data reported here validate our previous observation of a strong association between a functional polymorphism of the HLA-E gene and AS in Sardinia.

Moreover, unlike many polymorphisms, the ACTN3 R577X polymorphism is a functional polymorphism, with the XX genotype resulting in complete loss of function.

A functional polymorphism of the uPA gene has been described.

It is also possible that these SNPs are not the functional polymorphisms but are linked to a functional polymorphism elsewhere in the gene.

The 5-HTT gene has several polymorphisms, including a functional polymorphism consisting of a 44 base pair insertion/deletion in the 5′ promoter region, known as the serotonin transporter linked promoter region polymorphism (5-HTTLPR).

It may simply originate from LD with a functional polymorphism.