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Cell proliferation and migration was assessed as a function of growth factor loading and scaffold architecture.
These experimental observations support modeling persistence as a function of growth factor concentration as well as a function of the intrinsic probability of following a continuous path in a given direction.
The cell-level model, in turn, provides other benefits – modeling cell behavior at a level where not all molecular details are known, and when an event (e.g., proliferation, migration as a function of growth factor) or sequence of events governs capillary growth.
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(d) Growth rates at the center of the space line as a function of growth time.
Twenty-four-month neurodevelopmental function was analyzed as a function of growth status.
Growth factor receptor bound protein 7 (Grb7) is an adapter protein that functions as a downstream effector of growth factor mediated signal transduction.
The use of recombinant adenoviruses (Ad) to express secreted antagonists of growth factors represents a powerful strategy for studying physiologic functions of growth factor pathways in experimental animals.
In addition, the extracellular matrix also functions as a reservoir of growth factors derived from tumour or stromal cells.
Divergent functions of growth factors, such as FGF-2 or TGF-beta, in wound healing and cancer have also been reported.
It was found that the loaded concentration of the growth factor could easily be tuned as a function of the initial concentration of growth factor, and release of the cargo occurred without significant initial burst.
One possibility might be a function as a growth factor involved in the growth or plasticity of Kenyon cells.
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