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The phrase "as a first end point" is correct and usable in written English.
It can be used when discussing a preliminary or initial goal in a process or project.
Example: "We will evaluate the project's progress as a first end point before making further decisions."
Alternatives: "as an initial milestone" or "as a primary objective".
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The first end point was overall survival.
Whereas overall survival is the ultimate end-point, the case is made for utilizing other end-points according to the stage of disease and needs of the patient, for example utilizing disease-free survival as the first end-point in the adjuvant trial because of its relationship to overall survival.
Use of DFS as the first end-point, because it has consistently been validated as predating improvements in OS, is perfectly acceptable, as long as studies with novel interventions continue to collect the follow-up data to demonstrate that this linkage applies to newer biological interventions just as it does for conventional treatments.
Locoregional progression-free survival (LPFS) was defined as the time from diagnosis to tumor locoregional progression (the first end-point) or cancer-relative death (the second end-point).
Cardiovascular morbidity was defined as a composite end point, including death or first hospitalisation from coronary heart disease (ICD-9 codes 410 414, or ICD-10 codes I20 I25) and stroke (ICD-9 codes 431 436, or ICD-10 codes I61 I66).
As the first treatment end point, we considered UC symptoms, which patients consider as the most serious cause of impaired activities and quality of life.
In a second experiment, time to reach an MTD of 17 mm was used as a surrogate end point in accordance with UKCCCR guidelines (1998).
Second, and given the potential for post-recurrence survival to be influenced by a variety of factors (including the introduction of new therapies such as herceptin and taxanes for the treatment of advanced breast cancer), one could argue that first recurrence as an end point is likely to be more robust (once the impact of adjuvant therapy is taken into account) than breast cancer mortality.
It was analyzed as a secondary end point.
Serrated polyps were considered as a separate end point.
OS will be used as a primary end point.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com