The phrase "as a factor necessary" is not correct in standard written English.
It may be intended to convey the importance of a specific factor in a given context, but the phrasing is awkward and unclear.
Example: "In evaluating the success of the project, we must consider time management as a factor necessary for achieving our goals."
Alternatives: "as an essential factor" or "as a crucial element".
Rbm15 has been identified as a factor necessary for X-chromosome inactivation27, which is a representative context regulated by Polycomb silencing.
However, recent data supports a positive role of UVRAG by binding to BIF1 (also known as endophilin1), which was recently identified as a factor necessary for autophagosome formation [ 29].
In fact, there was no statistically significant difference between the two groups regarding patients with deep remission (DAS28-4ESR ≤1.98), weidentifiedntified as a factor necessary for successful ADA discontinuation.
Sox5 functions as a transcription factor necessary for chondrogenesis [19], [20], IHH promotes chondrogenesis as a cytokine [21], and PTHR1 mediates parathyroid hormone signaling as a specific receptor [18].
Implantation temperature is presented as a key factor necessary to achieve different Ti Cr surface compounds directly by ion implantation without the need of further treatments.
Previous studies have indicated that FGF signaling is required as a competence factor necessary for the response of embryonic amphibian cells to activin-like signals during development [39], [40], [60].
Foxi1 has also been recognised as a key factor necessary for correct patterning of distal nephron epithelium and adequate acid-base homeostasis in the kidney causing distal renal tubular acidosis in Foxi1-/ mice [ 3].
Therefore, until recently, coilin could be thought of as a crucial factor necessary to bring together the players required for CB function, but was not implicated directly in any of the activities ascribed to the CB.
As a further test, we stamped out the section of the knockout library known to contain the two different mating type strains with a knockout of the aod-5 gene (plate 1, co-ordinates C3 and C4), which we had previously identified as a transcription factor necessary for the expression of AOX (Chae et al. 2007b).
Should one not consider the presence of a suspected vector as an "obligatory" factor necessary for transmission, while the other factors are "enabling" or "facilitating" factors, therefore the risk zones should include only zones with potential or confirmed host animal presence.
Therefore, in an array of species, coilin is known to serve as an important factor necessary for CB formation but is not thought to play a role in the mechanisms that occur within the CB.
