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He added that it would take three to five years to train engineers to run such a factory, known as a fab.
On May 10th Paul Otellini, the boss of Intel, a big American chipmaker, put the price of a new chip factory (known as a fab) at around $10 billion.Happily for those that lack Intel's resources, there may be a cheaper option namely to mimic Mother Nature, who has been building tiny devices, in the form of living cells and their components, for billions of years, and has thus got rather good at it.
It is produced as a Fab fusion protein at approximately 35 mg/l in Escherichia coli.
This expression library, consisting of all the individual extracellular domains (ECDs), was constructed as a Fab fusion for each protein.
* An earlier version of this story read: "Philips bought IBM's Fishkill, N.Y., chip fabrication plant, known in the business as a fab, for an undisclosed sum".
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This mAb recognizes a highly conserved epitope in the HR-1 trimer and it is more effective as an Fab fragment as compared to intact IgG, a fact that is may be explained by the limited accessibility of the epitope, which is likely to be exposed only transiently on the cell surface during the viral entry process [70].
This Fc-Fc interaction departs from the present definition of RF as a Fab-Fc interaction hence the proposed dichotomic nomenclature of CRF vs. NRF.
But Dr Staniland reckons that, with enough tweaking, both of these objections could be dealt with.The advantage of this approach is that it might not be so capital-intensive as building a fab.
The sortase-tagging method has also been used by Harrenga and co-workers at Bayer to modify an Fab as well as by the Ploegh group to ligate peptides and proteins to the heavy chain of a full-length antibody.
Both ergosterol and diacylglycerol become enriched at the fusion microdomain of docked vacuoles, and this enrichment is sensitive to fusion-protein ligands such as Sec17p and an Fab fragment of affinity-purified antibody to Vam3p (Fratti et al., 2004).
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