Behaviour has been traditionally viewed as a driver of subsequent evolution because behavioural adjustments expose organisms to novel environments, which may result in a correlated evolution on other traits.
On the other hand, we favor the hypothesis that KSHV tumorigenesis is the culmination of multiple complex interactions between the virus and its host, and lytic replication as a driver of clonal evolution and systems dysfunction, as outlined in our model, constitutes but one aspect of this dynamic and complex process.
However, this does not mean one should discount CUB as a driver of eukaryotic evolution, as previously argued (Waldman et al. 2010).
Notably, a STAG2 mutation was identified as a driver of clonal evolution from myeloid dysplastic syndrome to secondary acute myeloid leukemia [ 24].
Polyploidy, also known as whole-genome duplication, is widely recognized as a major driver of evolution, diversification and speciation in angiosperms (Soltis et al. 2009; Wood et al. 2009; Robertson et al. 2010).
It has been proposed that the potency of Myc as an oncoprotein originates from its unrelenting assault on genomic integrity and serves as a driver of tumor cell evolution [41].
While CIN can act as a driver of cancer genome evolution and tumor progression, recent findings point to the existence of a threshold level beyond which CIN becomes a barrier to tumor growth and therefore can be exploited therapeutically.
While CIN can act as a driver of cancer genome evolution and tumor progression, recent findings point to the existence of a threshold level beyond which CIN becomes a barrier to tumor growth, and therefore, it can be exploited therapeutically.
Expression variation has been proposed as a driver of phenotypic changes, species evolution and domestication [ 10– 13].
Arguments for and against evolution as a driver of biological control outcomes mirror those arising at the boundaries of ecology and evolution in other contexts, including climate change (Travis and Futuyma 1993; Hoffmann and Sgrò 2011).
