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Open image in new window Figure 5 MCU interacts with VDAC1 and functions as a downstream of VDAC1.
In this study, we found MCU knockdown remarkably inhibited VDAC1 overexpression induced-cell death, suggesting MCU functions as a downstream of VDAC1 during oxidative stress-induced cell death.
Evidences suggest that Wnt signaling pathway modulates differentiation, proliferation and mineralization in bone formation as a downstream of BMP.
As a downstream of insulin signaling, phosphorylation of p70 S6 kinase was significantly augmented by AMPD1 deficiency in mice fed with high fat diet, but not with normal chow diet (right panel, Figure 1).
In terms of STAT3 signaling as a downstream of IL-6, preports reportsuggesteded that knocking down STAT3 using the shRNA technique in 4T1 cells leads to decreased invasiveness of the cells in vitro [ 51].
Giving Gli3 knockdown has been able to markedly rescue the defects in transplacental transport of Shh−/− placentas, we suggest that Gli3 functions as a downstream of Shh signal and has essential roles in blood vessel branching and proper construction of TIB.
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In this study, we explore the possible role of mdl-1 as a downstream effector of DAF-16 in the control of aging.
Our results identify 4-1BBL/4-1BB 4-1BBL/4-1BB 4-1BBL/4-1BB HDasi, especially of MS-275 anti-leukemia action in vitro.
Tight junction disruption is usually thought of as a downstream consequence of caspase cleavage during the apoptotic process.
In epithelial tissues, tight junction damage or disruption is usually thought of as a downstream consequence of caspase cleavage during the apoptotic process [ 15].
In epithelial tissues, tight junction damage is usually thought of as a downstream consequence of caspase cleavage during the apoptotic process [ 15].
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