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As a downstream effect of TrxR1 inactivation, ethaselen causes a dose-dependent thioredoxin oxidation and enhances the levels of cellular reactive oxygen species in A549 cells.
Our study suggests that IL-17 is implicated in the pathogenesis of this T cell-mediated model of uveitis in part through neutrophil chemotaxis as a downstream effect of IL-17.
"Whether they come as a downstream effect of the building blocks of basic research work someone else has done, or in a more deliberately applied way.
However, there is a dangerous lack of any sense of incongruity that human and domestic animal public health interventions occur only as a downstream effect of wildlife concerns.
In lab animals, amphetamine increases acetylcholine levels in certain brain regions as a downstream effect.
Together, these findings indicate the importance of enhanced glucose utilization as a downstream effect of CD28 signaling.
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This is either because, as above, there is a downstream effect on CO2 production, or because normal CO2 clearance is not required clinically to exert a positive effect on patient outcomes.
A downstream effect, such as altered transcription, would explain the delay in the onset of therapeutic action.
The mechanism for the induction of headache following increased serum levels of acetate may be through a downstream effect of acetate such as the accumulation of adenosine.
Furthermore, we show a loss of E-cadherin in a ZIP6-positive cell (arrow) as a direct downstream effect of Snail acting as a nuclear transcription factor.
We have identified a phosphorylation, ubiquitination and degradation cycle as a crucial downstream effect of the well-characterized inhibitor-induced acute dephosphorylation of LRRK2.
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