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It acts as a docking point for blood-borne messenger molecules called chemokines, which are supposed to rouse these cells into action against intruders.
Packed with the biggest entertainment stars, from Houdini to Vesta Tilley (a music hall performer who rose to fame as a male impersonator), with arcade games to amaze and astound, and often built as a docking point for pleasure steamships, the Victorian piers capitalised on their identity as a gateway to another world.
US28 had previously been shown to act as a docking point, or receptor, for the same immune system signaling molecules, called chemokines, that bind to CCR5, a receptor used by HIV strains that dominates during the early phases of infection.
Upon binding, the cytoplasmic tail of the integrin acts as a docking point for other signalling molecules such as focal adhesion kinase (FAK) (Christofori, 2003).
In the EGFR members of the TK family, this hydrophobic motif is used as a docking point for kinase activation through dimerization (Zhang et al., 2006; Jura et al., 2011).
The Ku complex becomes anchored at the break site and is then used as a docking point by DNA phosphokinases, which directly or indirectly create protein bridges to pull the two broken ends together, and finally re-join them by a DNA ligase [ 16, 18, 19].
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But Japan's Foreign Ministry says on its website that Japan established sovereignty over the islands by the mid 17th Century, its sailors using it as a "navigational port, docking point for ships and a rich fishing ground".
PCNA has been shown to complex with many BER enzymes, such as UNG, AAG, MUTYH, NEIL1, APE1, FEN1, and Lig1; accordingly, PCNA has been referred to as a docking station or communication point for such enzymes.
Nuclear cofactors function as docking points for various epigenetic regulators such as histone acetyltransferases (HATs) and histone deacetylases (HDACs) that modulate chromatin structures to activate or repress transcription.
Rigid receptor was used as a docking approach.
The erbB3 receptor contains six docking sites for PIP3, which serves as a docking site of the serine kinase Akt.
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