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For example, Nanavati et al. [19] keep their network as a directed network, in order to obtain information on the strongly connected component of the network, while Onnela et al. [14] rather focus on an undirected network, weighted by the sum of calls going in both directions.
The FFL is a loop as structure, but not as a directed network.
The regulon was reproduced as a directed network by combining literature data (summarised in [5]) for P.syringae, into an interaction network (Figure 1).
Transcription regulation can be modeled as a directed network with each node representing a gene and the proteins that it encodes, and an edge from one node to another if the former is a regulator of the latter.
As a particular example, here we focus on the nervous system of the worm C. elegans which is practically completely known [26], [27], and reconstruct its synaptic structure as a directed network (see Materials and Methods and Supporting Information Table S3).
(1) We represented the metabolic network, which is expressed as a directed network, as an undirected network.
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In the case of a directed network (such as the regulatory network), the number of common neighbors is calculated independently for incoming edges and outgoing edges.
When we have to compute the closeness of node v in a directed network, the directed network is regarded as an undirected network.
We describe the evacuation network within a stadium as a hierarchical directed network.
Airline network, including airports as network nodes and flight routes as directed network edges, has a lot of special features such as departure and arrival times, air ticket budget, flight capacity, transportation cost, etc.
Whenever the similarity value between two genes is above a threshold they are linked by an edge, which is referred to as a direct network inference approach (Kotera et al., 2012).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com