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This result, in contrast with the complex mechanical unfolding behaviors observed for ubiquitin, serves as a direct experimental demonstration of the Markovian behavior for the mechanical unfolding of a protein and reveals the complexity of the unfolding dynamics among structurally similar proteins.
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With DGE, the large fraction of reads arising from the 5'end make it easier to count as well as provide a direct experimental determination of the initiation site.
The bioinformatic analysis is supplemented and supported by substantive experimental evidence from the literature on a variety of biological systems [36], [37], as well as by a direct experimental test of the dependence of the efficacy of regulation on the distance of the BS from the TSS.
Hence, it is necessary to explore this question in a direct experimental manner, as was done by Nummenmaa et al. (2006) for emotional pictures by instructing the subjects to actively avoid looking at the emotional stimulus.
The SEM coupled to EDX eventually provides a direct experimental evidence of the enzymes immobilization within the microparticles as well as particle size.
A direct experimental method is subtractive hybridization.
This represents a direct experimental manipulation of the TACS stage of the tumor and therefore implicates stromal MMP13 as one driver of TACS evolution in breast tumors.
Given this inferred organization and integral-membrane orientation of the Hyq endo-hydrogenase complex (for which we as yet lack direct experimental evidence), one implication is obvious: the Hyq endo-hydrogenase might physically interact with Mo-dinitrogenase so as to channel evolved H2 as substrate for membrane-driven respiration and oxidative phosphorylation.
Despite enthusiastic debate, there is as yet no direct experimental evidence for the gradual evolution of the leaf pattern.
As for direct experimental observations of protein interactions in P. falciparum, we utilized a set of 2, 475 interactions among 1, 304 proteins that have been obtained by the modification of a yeast2hybrid method [ 27].
However, as is well known in community ecology, only a more direct, experimental approach can ascertain the consequences of these interactions for disease dynamics [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com