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The restriction to only two possible states for a molecule might appear as a crude simplification of the biological reality.
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As Backhaus and Faust indicated, it is a crude simplification to add the impact of a chemical where the most sensitive receptor is fish to one where the most sensitive receptor is an invertebrate (25).
But a crude simplification would go like this.
Assuming transmission parameters were constant in time throughout the epidemic is obviously a crude simplification.
Inevitably these models are a crude simplification, and their reliability is limited by the quality of the data available.
Obviously, this is a crude simplification and other authors have proposed more complicated models with a demographically correlated period/cohort or serial approaches [15,44].
Although being a crude simplification of biological reality, Boolean models are often able to reproduce the qualitative behavior of a system [ 2- 8].
For displacement piles, which are either pushed or hammered into the ground, such an approach is a very crude simplification.
Cumulus-derived measures of breast density are area based and are a somewhat crude simplification of the three-dimensional breast.
Of course, any crude simplification should be avoided: the author emphasizes that 18th century France was beginning to develop as a consumer society, in particular thanks to colonial products such as sugar and coffee.
As such, it can be classified as a "crude drug".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com